Nick Makris

From Complexity to Clarity

Leadership That Drives Impact.

Senior life science leader translating complex trade-offs into clear decisions and measurable outcomes. Grounded in experience at scale, leadership in practice, and a pragmatic lens on emerging AI technology.

Explore Focus Areas Read Newsletter (Substack)

The New Leadership Mandate: Escape Operational Overwhelm.

The modern leader is drowning in data and tasks. Clarity demands a disciplined approach, not just more information.

THE CHALLENGE

Operational overwhelm consumes time, stifles strategic thought, and slows key decisions. Strategy fades when leaders are constantly in reaction mode.

THE APPROACH

Apply experienced judgment and disciplined practice to separate signal from noise. Leverage emerging tech (AI) with clear intent, guided by a strong foundation.

THE RESULT

Regained focus and confidence to make better decisions. Time is redirected to leading people, disciplined execution, and creating long-term measurable impact.

Meet Nick Makris

Nick Makris professional headshot View LinkedIn
25+ Years Global
Life Sciences
Commercial Leader
Pharmacist
Experience at scale
Leadership
Emerging Tech/AI

With 25+ years of global life sciences leadership across Canada, US and the EU, I help leaders translate complexity into clear decisions and measurable outcomes.

I combine practical clinical experience as a Pharmacist with senior commercial and operational leadership across Big Pharma, Biopharma, Biotech, and Generics, often in high-unmet-need areas where tradeoffs matter most.

My work spans early development through launch and lifecycle management, with a focus on prioritization, execution discipline, and building teams that perform at scale. I am actively exploring how emerging technologies, including AI, can serve as a practical thinking partner to improve clarity, judgment, and decision speed.

Focus Areas

Experience At Scale, Leadership Practice, and Emerging Technology (AI).

Experience At Scale

25+ years of global life sciences leadership across Pharma, Biotech, and Generics. Proven results in high-stakes decisions spanning portfolio strategy, launches, and market access where trade-offs matter.

Leadership Practice

Author of Compounding Leadership, followed by 1,600+ leaders globally. Practical lessons on leading through complexity, strengthening judgment, and making better decisions over time.

Emerging Technology (AI)

Exploring AI as a thinking partner to help leaders surface insights, test assumptions, and accelerate clarity. Always in service of sound judgment, not as a substitute for it.

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